Ganciclovir

Ganciclovir is an active metabolite of the prodrug valganciclovir (Cay-13875) and an antiviral nucleoside derivative of 2'-deoxyguanosine (Cay-9002864). It reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM). Topical application of ganciclovir (0.15%) decreases disease severity and corneal leukocyte infiltration in a cat model of ocular feline herpesvirus-1 (FHV-1) epithelial infection. Ganciclovir (15 mg/kg) prevents allograft histologic injury and natural killer (NK) and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation. It induces tumor regression in a K-BALB murine sarcoma model using a mixed population of cells, which are positive or negative for expression of the gene encoding herpes simplex virus (HSV) thymidine kinase (TK). Formulations containing ganciclovir have been used in the treatment and prevention of CMV infections.Formal Name: 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one. CAS Number: 82410-32-0. Synonyms: 2'-NDG, 2'-Nor-2'-deoxyguanosine, 9-(1,3-dihydroxy-2-propoxymethyl)Guanine, BW 759, DHPG, GCV, RS 21592. Molecular Formula: C9H13N5O4. Formula Weight: 255.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.33 mg/ml. lambdamax: 254 nm. SMILES: O=C(N=C(N)N1)C2=C1N(C=N2)COC(CO)CO. InChi Code: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17). InChi Key: IRSCQMHQWWYFCW-UHFFFAOYSA-N.