gamma-Mangostin

gamma-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in vitro with an IC50 value of 23.6 µM. gamma-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 µM, respectively). It inhibits LPS-induced expression of IL-6, IL-10, and TNF-alpha in human macrophages in a concentration-dependent manner. Macrophage-conditioned media from macrophages pre-incubated with gamma-mangostin (30 µM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. gamma-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.Formal Name: 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one. CAS Number: 31271-07-5. Molecular Formula: C23H24O6. Formula Weight: 396.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): sparing solubility. SMILES: OC1=C2C(OC(C=C(O)C(O)=C3C/C=C(C)/C)=C3C2=O)=CC(O)=C1C/C=C(C)/C. InChi Code: InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3. InChi Key: VEZXFTKZUMARDU-UHFFFAOYSA-N. Origin: Plant/Mangosteen skin.