Gambogenic Acid

Gambogenic acid is a xanthone that has been found in G. hanburyi and has diverse biological activities. It reduces the proliferation of HeLa cervical cancer and HEL erythroleukemic cells (MICs = 12.5 and 3.13 µg/ml, respectively). Gambogenic acid reduces the proliferation of, and induces apoptosis in, HepG2 hepatocellular carcinoma cells, as well as induces cell cycle arrest at the G0/G1 phase in, and decreases migration of, M14 melanoma cells, in a concentration-dependent manner. Oral administration of lipid nanoparticles (LNPs) encapsulating gambogenic acid reduces tumor volume and weight in a 4T1 murine mammary carcinoma model.Formal Name: (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid. CAS Number: 173932-75-7. Molecular Formula: C38H46O8. Formula Weight: 630.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 213 nm. SMILES: OC(/C(C)=C\C[C@@]12[C@]3([C@@H]4C(C)(O2)C)C(C(C5=C(O)C(C/C=C(C)/CC/C=C(C)\C)=C(O)C(C/C=C(C)\C)=C5O3)=O)=C[C@H](C4)C1=O)=O. InChi Code: InChI=1S/C38H46O8/c1-20(2)10-9-11-22(5)13-15-25-30(39)26(14-12-21(3)4)33-29(31(25)40)32(41)27-18-24-19-28-36(7,8)46-37(34(24)42,38(27,28)45-33)17-16-23(6)35(43)44/h10,12-13,16,18,24,28,39-40H,9,11,14-15,17,19H2,1-8H3,(H,43,44)/b22-13+,23-16-/t24-,28+,37+,38-/m1/s1. InChi Key: RCWNBHCZYXWDOV-VSFMGBBVSA-N. Origin: Plant/Garcinia hanburyi.