Gadoteridol

Gadoteridol is a gadolinium-based MRI contrast agent. It enhances the visibility of intraparenchymal and meningeal tumors in an orthotopic rat model of brain cancer when administered at a dose of 0.25 mmol/kg. In vitro labeling of murine mesenchymal stem cells (MSCs) with gadoteridol and subsequent injection into mice has been used to track their migration to spinal cord injury lesions in vivo. Formulations containing gadoteridol have been used to visualize intra- and extracranial lesions in the head, neck, and spine.Formal Name: [10-[2-(hydroxy-kappaO)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-kappaN1,kappaN4,kappaN7,kappaN10,kappaO1,kappaO4,kappaO7]-gadolinium. CAS Number: 120066-54-8. Synonyms: Gd-HP-D03A, SQ 32,692. Molecular Formula: C17H29GdN4O7. Formula Weight: 558.7. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: CC1[OH][Gd+3]([N](CC2)(CC3)CC4=O)([N]53CC6=O)([N]72C1)([O-]6)([O-]4)([O-]8)[N](CC7)(CC5)CC8=O. InChi Code: InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26,/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28),/q,+3/p-3. InChi Key: DPNNNPAKRZOSMO-UHFFFAOYSA-K.