G-5758

Description: G-5758 is an orally active IRE1alpha inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown. Target: IRE1, Liposome. Smiles: O(C1=C(C=CC=N1)C2=NC(N[C@H]3C[C@H](F)CNC3)=NC=C2)C4=C(F)C(F)=C(NS(CC5=CC=CC=C5)(=O)=O)C(F)=C4