Fusidic Acid (sodium salt)

Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all). Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively). Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-alpha and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.Formal Name: (4alpha,8alpha,9beta,13alpha,14beta)-16beta-(acetyloxy)- 3alpha,11alpha-dihydroxy-29-nordammara-17Z(20),24-dien-21-oic acid, monosodium salt. CAS Number: 751-94-0. Synonyms: SQ 16,360. Molecular Formula: C31H47O6 . Na. Formula Weight: 538.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 14 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 12.5 mg/ml. SMILES: O[C@@H]1CC[C@@]2(C)[C@](CC[C@@]3(C)[C@@]2([H])[C@H](O)C[C@]4([H])[C@]3(C)C[C@H](OC(C)=O)/C4=C(C([O-])=O)/CC/C=C(C)/C)([H])[C@@H]1C.[Na+]. InChi Code: InChI=1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32,/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36),/q,+1/p-1/b26-20-,/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-,/m0./.