Fraxin

Fraxin is a coumarin glycoside that has been found in Fraxinus and has anti-inflammatory activity. It inhibits formation of 5-hydroxyeicosatetraenoic acid (5-HETE) from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in rat polymorphonuclear leukocytes when used at concentrations ranging from 1 to 1,000 µM in vitro. Fraxin inhibits production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells (IC50 = 84.5 µM). It also decreases LPS-induced TNF-alpha, IL-6, IL-1beta, NF-?B, and NLRP3 expression in the lung in mouse models of acute lung injury and endotoxic shock when administered at doses ranging from 10 to 40 mg/kg.Formal Name: 8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2H-1-benzopyran-2-one. CAS Number: 524-30-1. Synonyms: Fraxetol 8-glucoside, Fraxoside. Molecular Formula: C16H18O10. Formula Weight: 370.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): 2 mg/ml. lambdamax: 229, 344 nm. SMILES: OC[C@H]1O[C@@H](OC2=C(O)C(OC)=CC(C=C3)=C2OC3=O)[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C16H18O10/c1-23-7-4-6-2-3-9(18)25-14(6)15(11(7)20)26-16-13(22)12(21)10(19)8(5-17)24-16/h2-4,8,10,12-13,16-17,19-22H,5H2,1H3/t8-,10-,12+,13-,16+/m1/s1. InChi Key: CRSFLLTWRCYNNX-QBNNUVSCSA-N.