Forsythoside A

Forsythoside A is a phenylethanoid glycoside that has been found in F. suspensa and has diverse biological activities. It is active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively). Forsythoside A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals with an EC50 value of 6.3 µg/ml. It reduces apoptosis induced by amyloid-beta (25-35) (Abeta (25-35)) in PC12 cells when used at concentrations of 10 and 25 µM. Forsythoside A (15, 30, and 60 mg/kg per day) reduces increases in bronchoalveolar lavage fluid (BALF) levels of TNF-alpha, IL-6, and IL-1beta and neutrophil and macrophage infiltration induced by cigarette smoke in a mouse model of chronic obstructive pulmonary disease (COPD). It decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia when administered at doses of 120 and 240 mg/kg per day.Formal Name: 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-Glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]. CAS Number: 79916-77-1. Synonyms: Forsythiaside. Molecular Formula: C29H36O15. Formula Weight: 624.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 220, 333 nm. SMILES: OC(C=C1)=C(O)C=C1CCO[C@@H]2O[C@H](CO[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)[C@H](O)[C@H]2O. InChi Code: InChI=1S/C29H36O15/c1-13-22(35)23(36)25(38)29(42-13)41-12-20-27(44-21(34)7-4-14-2-5-16(30)18(32)10-14)24(37)26(39)28(43-20)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29+/m0/s1. InChi Key: DTOUWTJYUCZJQD-UJERWXFOSA-N.