FMF-04-159-2

FMF-04-159-2 is an inhibitor of TAIRE family kinases. It binds to Cdk14 and Cdk16 (IC50s = 88 and 10.1 nM, respectively) and selectively inhibits Cdk14, Cdk16, Cdk17, and Cdk18 over a panel of 16 additional kinases at 1 µM but does inhibit Cdk2 and Cdk10 by greater than 70% at 1 µM.Formal Name: N-[1-[[3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6-trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide. CAS Number: 2364489-81-4. Molecular Formula: C28H30Cl3N7O5S. Formula Weight: 683.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(C(C(Cl)=CC(Cl)=C1)=C1Cl)NC2=CNN=C2C(NC(CC3)CCN3[S](=O)(C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)=O)=O. InChi Code: InChI=1S/C28H30Cl3N7O5S/c1-37(2)10-4-7-24(39)33-19-5-3-6-20(15-19)44(42,43)38-11-8-18(9-12-38)34-28(41)26-23(16-32-36-26)35-27(40)25-21(30)13-17(29)14-22(25)31/h3-7,13-16,18H,8-12H2,1-2H3,(H,32,36)(H,33,39)(H,34,41)(H,35,40)/b7-4+. InChi Key: HZPYSAHDRSBARR-QPJJXVBHSA-N.