Flavokawain A

Flavokawain A is a chalcone that has been found in P. methysticum and has diverse biological activities. It activates nuclear factor erythroid 2-related factor 2 (Nrf2) and heat shock factor 1 (Hsf1, EC50s = 14.1 and 7.9 µM, respectively, in reporter assays), increases glutathione (GSH) levels, and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells. Flavokawain A (10 and 20 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, nitric oxide (NO), and prostaglandin E2 (PGE2, Cay-14010) levels in RAW 264.7 macrophages. It induces apoptosis in T24 bladder cancer cells when used at a concentration of 12.5 µg/ml. Flavokawain A (50 mg/kg) reduces tumor growth in an EJ bladder cancer mouse xenograft model.Formal Name: (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one. CAS Number: 37951-13-6. Synonyms: Flavokavain A, 4-methoxy Flavokawain B. Molecular Formula: C18H18O5. Formula Weight: 314.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml. lambdamax: 361 nm. SMILES: COC1=C(C(O)=CC(OC)=C1)C(/C=C/C2=CC=C(C=C2)OC)=O. InChi Code: InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+. InChi Key: CGIBCVBDFUTMPT-RMKNXTFCSA-N. Origin: Plant/Piper methysticum.