Filipin II

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex (Cay-25073). It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 µg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 µg/ml).Formal Name: 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-hexyl-17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,23E,25E-pentaen-2-one. CAS Number: 38620-77-8. Molecular Formula: C35H58O10. Formula Weight: 638.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@H](CCCCCC)[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O. InChi Code: InChI=1S/C35H58O10/c1-4-5-6-13-16-31-34(43)23-30(40)21-28(38)19-26(36)18-27(37)20-29(39)22-33(42)24(2)15-12-10-8-7-9-11-14-17-32(41)25(3)45-35(31)44/h7-12,14-15,17,25-34,36-43H,4-6,13,16,18-23H2,1-3H3/b8-7+,11-9+,12-10+,17-14+,24-15+/t25-,26+,27-,28+,29-,30+,31-,32+,33+,34+/m1/s1. InChi Key: YMIXNQVKVPYZHL-YWSRBNGNSA-N. Origin: Bacterium/Streptomyces sp..