Ferroptosis-IN-17

Description: Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 µM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders. Target: Ferroptosis, Glutathione Peroxidase. Smiles: CCNC(=O)C1=CC(=C(C=C1)NC2CCCCC2)NS(=O)(=O)C3=CC=C(C=C3)[N+](=O)[O-]