FAK activator 1

Description: ZINC40099027 is a specific adhesion plaque kinase (FAK) activator that promotes gastric mucosal repair in persistent aspirin-associated gastric injury through activation of adhesion plaque kinase, activates human adhesion plaque kinase by accelerating the enzyme activity of the structural domain of FAK kinase, activates cytosolic FAK, and promotes intestinal epithelial wound closure. Target: FAK. Smiles: O=C(NC1=CC(=CC=C1N2CCOCC2)C(F)(F)F)N3CCCC3C4=CC=C(OC)C=C4. References: Wang Q, et al. Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing. ACS Med Chem Lett. 2021 Feb 16,12(3):356-364.