Evocalcet

Evocalcet is an agonist of the calcium-sensing receptor (CaSR). It induces intracellular calcium release in HEK293 cells expressing human CaSR (EC50 = 92.7 nM). Evocalcet reduces serum levels of parathyroid hormone (PTH) and calcium when administered at doses of 0.3 and 0.1 mg/kg, respectively, in non-nephrectomized and 5/6 nephrectomized rats. It also reduces serum levels of PTH without inducing emesis in marmosets when administered at doses of 0.3 and 0.5 mg/kg.Formal Name: 4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]-benzeneacetic acid. CAS Number: 870964-67-3. Synonyms: KHK7580, MT-4580. Molecular Formula: C24H26N2O2. Formula Weight: 374.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 224 nm. SMILES: C[C@H](C1=CC=CC2=C1C=CC=C2)N[C@@H]3CN(C4=CC=C(CC(O)=O)C=C4)CC3. InChi Code: InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1. InChi Key: RZNUIYPHQFXBAN-XLIONFOSSA-N.