EUK 118

EUK 8 and EUK 134 (Cay-10006329) are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. EUK 118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 118 exhibits a catalase activity of 35 µM O2 formed/minute from 10 mM hydrogen peroxide, which is more than four times lower that that observed for EUK 8 under the same conditions. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 and EUK 8 with IC50 values of 2 and 0.7 µM, respectively. EUK 118 did not protect human dermal fibroblasts against hydrogen peroxide-induced cell death.Formal Name: (acetato-kappaO)[[2,2'-[1,2-ethanediylbis[(nitrilo-kappaN)methylidyne]]bis[3,5-dimethoxyphenolato-kappaO]](2-)]-manganese. CAS Number: 186299-34-3. Molecular Formula: C22H25MnN2O8. Formula Weight: 500.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.2 mg/ml. SMILES: CC([O-][Mn+3]([N]1=CC2=C3OC)([O-]C2=CC(OC)=C3)([O-]C4=CC(OC)=C5)[N](CC1)=CC4=C5OC)=O. InChi Code: InChI=1S/C20H24N2O6.C2H4O2.Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4,1-2(3)4,/h7-12,23-24H,5-6H2,1-4H3,1H3,(H,3,4),/q,,+3/p-3/b21-11+,22-12+,,. InChi Key: HBERMORFIFQRRW-AIMLMLFYSA-K.