Eucalyptol

Eucalyptol is a bicyclic monoterpene that has been found in Eucalyptus and other plants, including C. sativa and has diverse biological activities, including anti-inflammatory, decongestant, antinociceptive, and insect repellent properties. Eucalyptol (10 µM) inhibits TNF-alpha, IL-1beta, IL-4, and IL-5 production by primary human lymphocytes stimulated by ionomycin (Cay-10004974) and phorbol 12-myristate 13-acetate (PMA, Cay-10008014). It also decreases LPS-induced mucus production by primary human nasal turbinate slices when used at a concentration of 10 µM. Eucalyptol (400 mg/kg) decreases carrageenan-induced hind paw edema in rats and reduces the time spent licking the hind paw in a formalin-induced nociception test in mice. It inhibits A. aegypti mosquitoes from feeding on anesthetized gerbils when applied topically at a concentration of 10% and from laying eggs in an ovipositional bioassay when used at a concentration of 1% in standing water. Formulations containing eucalyptol have been used in mouthwash and cough suppressants.Formal Name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane. CAS Number: 470-82-6. Synonyms: NSC 6171. Molecular Formula: C10H18O. Formula Weight: 154.3. Purity: >98%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 20 mg/ml. SMILES: CC12CCC(CC2)C(C)(C)O1. InChi Code: InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3. InChi Key: WEEGYLXZBRQIMU-UHFFFAOYSA-N.