Estrone

Description: Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENE DIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR, Endogenous Metabolite. Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(O)=C4)[C@@H]1CCC2=O. References: Margeat E, et al. J Mol Biol. 2003 Feb 7,326(1):77-92.