ERB 041

ERB 041 is an estrogen receptor beta (ERbeta) agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively). It is selective for ERbeta over ERalpha (IC50s = 1,200, 620, and 750 nM for human, rat, and mouse ERalpha, respectively). ERB 041 induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERbeta (EC50 = 20 nM). In vivo, ERB 041 (0.1 and 0.3 mg/kg) inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease. It reduces joint swelling in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. ERB 041 (10 mg/kg) also reduces lesion formation in a mouse model of endometriosis.Formal Name: 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol. CAS Number: 524684-52-4. Molecular Formula: C15H10FNO3. Formula Weight: 271.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml. lambdamax: 216, 247, 309, 338 nm. SMILES: C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1. InChi Code: InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2. InChi Key: MQIMZDXIAHJKQP-UHFFFAOYSA-N.