Eptifibatide (acetate)

Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa, Kd = 120 nM) that inhibits platelet aggregation. Eptifibatide prevents binding of the adhesion proteins fibrinogen and von Willebrand factor to GPIIb/IIIa on the surface of activated platelets to prevent aggregation and thrombus formation. It inhibits ADP-induced citrated blood aggregation (IC50 = 0.11-0.22 µg/ml) in vitro and in vivo (IC50 = 52 µg/ml in porcine plasma). Formulations containing eptifibatide have been used to reduce risk of thrombolysis in myocardial infarction in patients undergoing percutaneous coronary intervention.Formal Name: N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic (1->6)-disulfide, acetate. CAS Number: 881997-86-0. Molecular Formula: C35H49N11O9S2 . XC2H4O2. Formula Weight: 832.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 14 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 222, 283 nm. SMILES: O=C([C@H](CC1=CNC2=C1C=CC=C2)N3)N4[C@](CCC4)([H])C(N[C@H](C(N)=O)CSSCCC(N[C@@H](CCCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C3=O)=O)=O)=O)=O.CC(O)=O. InChi Code: InChI=1S/C35H49N11O9S2.C2H4O2/c36-30(51)25-18-57-56-13-10-27(47)42-22(8-3-4-11-39-35(37)38)31(52)41-17-28(48)43-23(15-29(49)50)32(53)44-24(14-19-16-40-21-7-2-1-6-20(19)21)34(55)46-12-5-9-26(46)33(54)45-25,1-2(3)4/h1-2,6-7,16,22-26,40H,3-5,8-15,17-18H2,(H2,36,51)(H,41,52)(H,42,47)(H,43,48)(H,44,53)(H,45,54)(H,49,50)(H4,37,38,39),1H3,(H,3,4)/t22-,23-,24-,25-,26-,/m0./s1. InChi Key: KWKBRYJYRIUYEI-QMYFOHRPSA-N.