Eprinomectin

Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is composed of eprinomectin B1a (Cay-28130) and eprinomectin B1b (Cay-27994). Eprinomectin (>0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg.Formal Name: (4''R)-4''-(acetylamino)-4''-deoxy-avermectin B1. CAS Number: 123997-26-2. Synonyms: MK-397. Molecular Formula: C50H75NO14 (for B1a). Formula Weight: 914.1. Purity: >95% (mixture of B1a and B1b). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 246 nm. SMILES: C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@@H](NC(C)=O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(C=C[C@H](C)[C@]([C@H](CC)C)([H])O7)O6.C/C([C@@H](O[C@@]8([H])C[C@H](OC)[C@@H](O[C@]9([H])O[C@@H](C)[C@@H](NC(C)=O)[C@@H](OC)C9)[C@H](C)O8)[C@@H](C)/C=C/C=C(CO%10)/[C@@]([C@@]%10([H])[C@H](O)C(C)=C%11)(O)[C@]%11([H])C%12=O)=C\C[C@]%13([H])C[C@@](O%12)([H])C[C@]%14(C=C[C@H](C)[C@@H](C(C)C)O%14)O%13. InChi Code: InChI=1S/C50H75NO14.C49H73NO14/c1-12-26(2)45-29(5)18-19-49(65-45)24-36-21-35(64-49)17-16-28(4)44(27(3)14-13-15-34-25-58-47-43(53)30(6)20-37(48(54)61-36)50(34,47)55)62-41-23-39(57-11)46(32(8)60-41)63-40-22-38(56-10)42(31(7)59-40)51-33(9)52,1-25(2)43-28(5)17-18-48(64-43)23-35-20-34(63-48)16-15-27(4)44(26(3)13-12-14-33-24-57-46-42(52)29(6)19-36(47(53)60-35)49(33,46)54)61-40-22-38(56-11)45(31(8)59-40)62-39-21-37(55-10)41(30(7)58-39)50-32(9)51/h13-16,18-20,26-27,29,31-32,35-47,53,55H,12,17,21-25H2,1-11H3,(H,51,52),12-15,17-19,25-26,28,30-31,34-46,52,54H,16,20-24H2,1-11H3,(H,50,51)/b14-13+,28-16+,34-15+,13-12+,27-15+,33-14+/t26-,27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45+,46-,47+,49+,50+,26-,28-,30-,31-,34+,35-,36-,37-,38-,39-,40-,41+,42+,43+,44-,45-,46+,48+,49+/m00/s1. InChi Key: VBPOFUHCXIRECN-SXLRFJQHSA-N.