EML4-ALK Kinase Inhibitor 1

EML4-ALK kinase inhibitor 1 is an inhibitor of the anaplastic lymphoma kinase (ALK) fusion protein EML4-ALK (IC50 = 1 nM). It inhibits the growth of Ba/F3 cells expressing EML4-ALK (IC50 = 9.7 nM). In vivo, EML4-ALK kinase inhibitor 1 (10 mg/kg) induces tumor regression in mice xenografted with NIH3T3 cells expressing EML4-ALK.. SMILES: CN1CCN(C2CCN(C(C=CC(NC3=NC(N[C@@H]4CC[C@H](CC4)OC)=C(N=C3C(N)=O)CC)=C5)=C5OC)CC2)CC1. InChi Code: InChI=1S/C31H48N8O3/c1-5-25-30(33-21-6-9-24(41-3)10-7-21)36-31(28(35-25)29(32)40)34-22-8-11-26(27(20-22)42-4)39-14-12-23(13-15-39)38-18-16-37(2)17-19-38/h8,11,20-21,23-24H,5-7,9-10,12-19H2,1-4H3,(H2,32,40)(H2,33,34,36)/t21-,24-. InChi Key: KBHZCRDGGWIHQF-SAIGFBBZSA-N