Emeramide

Emeramide is an antioxidant heavy metal chelator. It prevents methylmercury-induced glutathione (GSH) loss, and cytotoxicity to, isolated mouse aortic endothelial cells when used at a concentration of 50 µM. Emeramide (50 µM) also prevents reactive oxygen species (ROS) production and cytotoxicity induced by bleomycin (Cay-13877) in primary bovine pulmonary artery endothelial cells. It increases survival of rats in a model of mercury chloride-induced toxicity when administered at a dose of 2 mg/kg.Formal Name: N1,N3-bis(2-mercaptoethyl)-1,3-benzenedicarboxamide. CAS Number: 351994-94-0. Synonyms: BDTH2, NBMI. Molecular Formula: C12H16N2O2S2. Formula Weight: 284.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. SMILES: O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS. InChi Code: InChI=1S/C12H16N2O2S2/c15-11(13-4-6-17)9-2-1-3-10(8-9)12(16)14-5-7-18/h1-3,8,17-18H,4-7H2,(H,13,15)(H,14,16). InChi Key: JUTBAVRYDAKVGQ-UHFFFAOYSA-N.