EM-12-FS

An NTAQ1 degrader, binds to CRBN (IC50 = 256 nM) and covalently labels His353, reduces the levels of NTAQ1 in MOLT-4 cells in a NEDDylation-dependent manner at 1 and 5 µM. Formulation: A solid. InChI: InChI=1S/C13H11FN2O6S/c14-23(20,21)22-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18). InChIKey: RXYXBYLQECASPH-UHFFFAOYSA-N. SMILES: O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O