ELOVL6-IN-5

Description: ELOVL6-IN-5 (compound B) acts as an inhibitor targeting the elongase enzyme of the long-chain fatty acid family 6 (ELOVL6). This enzyme is pivotal in the elongation process of saturated and monounsaturated long-chain fatty acids, marking it as a strategic target for diabetes intervention. In a mouse model of diet-induced obesity (DIO), ELOVL6-IN-5 effectively reduces hepatic fatty acid levels. However, it fails to enhance insulin sensitivity. Smiles: O=C(NC1=CC=C(C=C1)C(F)(F)F)N2C3CCC2CC(C3)S(=O)(=O)C4=NC=CC=C4