Eleutheroside A

Eleutheroside A is a natural phytosterol glycoside that exerts multiple bioactivities, like anticancer, anti-inflammatory, immunomodulatory, antibacterial and antioxidant, via modulation of cell signaling, oxidative stress, and immune responses. It modulates immune, metabolic and tumor-associated pathways. Eleutheroside A can inhibit the PI3K/AKT1/mTOR signaling pathway in myeloid-derived suppressor cells (MDSCs), thereby reducing their glycolytic activity and immunosuppressive function in the tumor microenvironment of gastric cancer, which leads to enhanced CD4+/CD8+ T-cell infiltration and slowed tumor growth in vivo.