eIF4A i28

Description: eIF4A i28, an inhibitor of the eukaryotic initiation factor-4A (eIF4A) with an IC50 of 8.60 µM in an eIF4A ATPase assay, effectively reduces the viability of BJAB Burkitt lymphoma cells, as indicated by an EC50 of 0.46 µM in a CellTiter-Glo (CTG) luminescence cell viability assay. This compound functions as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor. Target: Others. Smiles: CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1