EFdA

EFdA is a nucleoside reverse transcriptase inhibitor (NRTI). It inhibits HIV-1 reverse transcriptase via multiple mechanisms. EFdA inhibits replication of the HIV-1 strain HIV-1 IIIb, the laboratory isolate HIV NL4-3, and the clinical isolate HIV-2 EHO in MT-4 cells (EC50s = 73, 50, and 98 pM, respectively). It is also active against drug-resistant HIV with EC50 values ranging from 0.23 to 23 nM in a multinuclear activation of a galactosidase indicator (MAGI) assay. EFdA (1 and 10 mg/kg per day) prevents infection with HIV JR-CSF in humanized mice.Formal Name: 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine. CAS Number: 865363-93-5. Synonyms: 4'Ed2FA, 4'-ethynyl-2-fluoro-2'-Deoxyadenosine, EFDA, MK-8591. Molecular Formula: C12H12FN5O3. Formula Weight: 293.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 263 nm. SMILES: FC1=NC(N)=C2C(N([C@@]3([H])C[C@H](O)[C@@](C#C)(CO)O3)C=N2)=N1. InChi Code: InChI=1S/C12H12FN5O3/c1-2-12(4-19)6(20)3-7(21-12)18-5-15-8-9(14)16-11(13)17-10(8)18/h1,5-7,19-20H,3-4H2,(H2,14,16,17)/t6-,7+,12+/m0/s1. InChi Key: IKKXOSBHLYMWAE-QRPMWFLTSA-N.