Ebselen

Description: Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity. Target: COX, HIV Protease, Phosphatase, Calcium Channel, Virus Protease. Smiles: O=C1N([Se]C=2C1=CC=CC2)C3=CC=CC=C3. References: Schewe T. Gen Pharmacol, 2009, 26 (6): 1153-69.