EB 1089

EB 1089 is a synthetic vitamin D analog that is 50-200 times more potent than calcitriol (Cay-71820) at inhibiting cell proliferation and differentiation, yet displays reduced calcemic activity compared to that of calcitriol. It has been shown to promote tumor regression in vitro by inducing apoptosis.Formal Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol. CAS Number: 134404-52-7. Synonyms: Seocalcitol. Molecular Formula: C30H46O3. Formula Weight: 454.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL. lambdamax: 233, 264 nm. SMILES: C=C1[C@@H](O)C[C@H](O)C/C1=C/C=C2[C@@]3([H])[C@]([C@]([C@H](C)/C=C/C=C/C(CC)(O)CC)([H])CC3)(C)CCC/2. InChi Code: InChI=1S/C30H46O3/c1-6-30(33,7-2)18-9-8-11-21(3)26-15-16-27-23(12-10-17-29(26,27)5)13-14-24-19-25(31)20-28(32)22(24)4/h8-9,11,13-14,18,21,25-28,31-33H,4,6-7,10,12,15-17,19-20H2,1-3,5H3/b11-8+,18-9+,23-13+,24-14-/t21-,25-,26-,27+,28+,29-/m1/s1. InChi Key: LVLLALCJVJNGQQ-SEODYNFXSA-N.