E6 Berbamine

E6 Berbamine is a calmodulin inhibitor that disrupts the activity of calmodulin-dependent enzymes such as myosin light chain kinase (IC50 = 8 µM) and phosphodiesterase 1A (IC50 = 0.53 µM). It is also reported to inhibit P-glycoprotein activity in purified primary cultured rat brain microvessel endothelial cells at 10 µM.Formal Name: 3,4,4aS,5,16aR,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol-4-nitrobenzoate. Synonyms: Berbamine p-nitrobenzoate, O-(4-Nitrobenzoyl)berbamine. Molecular Formula: C44H43N3O9. Formula Weight: 757.8. Purity: >98% (mixture of enantiomers). Formulation: (Request formulation change), A solid. Solubility: DMSO: 25mM, Ethanol: 25mM. SMILES: COC1=C(C2=C(CCN([C@]2([H])CC3=CC=C(OC(C4=CC=C([N+]([O-])=O)C=C4)=O)C(OC5=CC=C(C[C@@]67[H])C=C5)=C3)C)C=C1OC)OC8=CC6=C(CCN7C)C=C8OC. InChi Code: InChI=1S/C44H43N3O9/c1-45-18-16-29-23-37(51-3)39-25-33(29)34(45)20-26-6-13-32(14-7-26)54-38-22-27(8-15-36(38)56-44(48)28-9-11-31(12-10-28)47(49)50)21-35-41-30(17-19-46(35)2)24-40(52-4)42(53-5)43(41)55-39/h6-15,22-25,34-35H,16-21H2,1-5H3/t34-,35+/m0/s. InChi Key: PUAVTDKYTXNVBU-OIDHKYIRSA-N.