dTRIM24

Description: dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24. Target: PROTACs, Others. Smiles: O(C1=C(NS(=O)(=O)C2=CC(C(NCCOCCOCCO CC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)C(C)(C)C)=O)=O)=CC=C2)C=C6C(=C1)N(C)C(=O)N6C)C7=CC(OCCC)=CC=C7. References: Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 , 14(4):405-412.