DSPE-PEG-Maleimide (MW 5000)

Description: DSPE-PEG-Maleimide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. Target: Others. Smiles: CCCCCCCCCC CCCCCCCC(O[C@](COP(OCCNC(COCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)([O-])=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)=O.[MW 5000].[Na+].[n]. References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct,36:553-562.