DPNB-ABT 594

Description: DPNB-ABT 594 is a nitrobenzyl-caged ABT 594, a selective alpha4beta2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation, one-photon uncaging requires illumination at 410 nm for 1.5-3 ms, two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms. Target: Others. References: Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192