Doxifluridine

Doxifluridine is an intermediary prodrug of fluorouracil (Cay-14416), the pyrimidine analog that inhibits thymidylate synthase selectively in tumor cells, interfering with DNA synthesis. Doxifluridine is one of two intermediary metabolites formed during metabolic conversion of the chemotherapeutic prodrug, capecitabine (Cay-10487), to fluorouracil.Formal Name: 5'-deoxy-5-fluoro-uridine. CAS Number: 3094-09-5. Synonyms: 5-DFUR, Ro 21-9738. Molecular Formula: C9H11FN2O5. Formula Weight: 246.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 269 nm. SMILES: OC1[C@@H](C)O[C@@H](N2C=C(F)C(N([H])C2=O)=O)C1O. InChi Code: InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5?,6?,8-/m1/s1. InChi Key: ZWAOHEXOSAUJHY-MMRIIKACSA-N.