DL-threo-beta-Hydroxyaspartic Acid

DL-threo-beta-Hydroxyaspartic acid is an inhibitor of excitatory amino acid transporters (EAATs). It inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively) as well as inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 2.5 µM) voltage-clamped at -60 mV. Intrathecal administration of DL-threo-beta-hydroxyaspartic acid (7.5 and 15 µg/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats.Formal Name: rel-3R-hydroxy-D-aspartic acid. CAS Number: 4294-45-5. Synonyms: DL-THA, DL-threo-3-Hydroxyaspartic Acid. Molecular Formula: C4H7NO5. Formula Weight: 149.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Chloroform: Slightly soluble, DMF: Slightly soluble, DMSO: Slightly soluble, Ethanol: Slightly soluble, PBS (pH 7.2): Slightly soluble, Water: Slightly soluble. SMILES: OC([C@@H](O)[C@H](N)C(O)=O)=O. InChi Code: InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1. InChi Key: YYLQUHNPNCGKJQ-LWMBPPNESA-N.