DL-Mevalonolactone

DL-Mevalonolactone is the delta-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Cay-10010344, Cay-10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.Formal Name: tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one. CAS Number: 674-26-0. Synonyms: DL-Mevalonic Acid Lactone, (±)-Mevalonolactone, NSC 90804. Molecular Formula: C6H10O3. Formula Weight: 130.1. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: O=C1CC(O)(C)CCO1. InChi Code: InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3. InChi Key: JYVXNLLUYHCIIH-UHFFFAOYSA-N.