DL-AP4

DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA (Cay-14581), L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate (Cay-14584), quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.Formal Name: 2-amino-4-phosphono-butanoic acid. CAS Number: 6323-99-5. Synonyms: NSC 30079, NSC 354086. Molecular Formula: C4H10NO5P. Formula Weight: 183.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. SMILES: OP(CCC(C(O)=O)N)(O)=O. InChi Code: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10). InChi Key: DDOQBQRIEWHWBT-UHFFFAOYSA-N.