DK-AH 269

DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells). DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart. Using telemetric ECG recordings in mice, it reduced heart rate in a dose-dependent fashion with an ED50 of 1.2 mg/kg. DK-AH 269 also has proarrhythmic properties at concentrations higher than 5 mg/kg.Formal Name: 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride. CAS Number: 186097-54-1. Synonyms: Cilobradine. Molecular Formula: C28H38N2O5 . HCl. Formula Weight: 519.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 281 nm. SMILES: COC1=CC=C(CCN2CC(CN(CCC(C=C(OC)C(OC)=C3)=C3C4)C4=O)CCC2)C=C1OC.Cl. InChi Code: InChI=1S/C28H38N2O5.ClH/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31,/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3,1H. InChi Key: MTAKUIYCCYKGJJ-UHFFFAOYSA-N.