Dizocilpine Maleate

Description: Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) with Kd of 37.2 nM in rat brain membranes. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Target: NMDAR, iGluR. Smiles: OC(=O)\C=C/C(O)=O.C[C@]12N[C@H](Cc3ccccc13)c1ccccc21. References: Wong EH, et al. Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108.