Disulfiram-d20

Disulfiram-d20 is intended for use as an internal standard for the quantification of disulfiram (Cay-15303) by GC- or LC-MS. Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM). It also inhibits the copper-dependent enzyme dopamine beta-hydroxylase, which prevents the breakdown of dopamine. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 µM) and 26S proteasome (IC50 = 20 µM) from MDA-MB-0231 breast cancer cells. Disulfiram (at 250 nM) induces reactive oxygen species, activates JNK and p38 pathways, and inhibits NF-kappaB activity, which suppresses self-renewal in cancer stem cells.Formal Name: bis(1,1,2,2,2-pentadeuterioethyl)carbamothioylsulfanyl N,N-bis(1,1,2,2,2-pentadeuterioethyl)carbamodithioate. CAS Number: 1216403-88-1. Synonyms: Tetraethylthiuram disulfide-d20. Molecular Formula: C10D20N2S4. Formula Weight: 316.7. Purity: >99% deuterated forms (d1-d20). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Methanol: soluble. SMILES: S=C(N(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])SSC(N(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=S. InChi Code: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3/i1D3,2D3,3D3,4D3,5D2,6D2,7D2,8D2. InChi Key: AUZONCFQVSMFAP-DEHFLJNXSA-N.