Diquafosol (sodium salt)

Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays). It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease. Formulations containing diquafosol have been used in the treatment of dry eye disease.Formal Name: uridine 5'-(pentahydrogen tetraphosphate), P'''->5'-ester with uridine, tetrasodium salt. CAS Number: 211427-08-6. Synonyms: INS365, KPY 998. Molecular Formula: C18H22N4O23P4 . 4Na. Formula Weight: 878.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 263 nm. SMILES: O=P(OC[C@H]1O[C@@](N2C=CC(NC2=O)=O)([C@@H]([C@@H]1O)O)[H])([O-])OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@@](N4C(NC(C=C4)=O)=O)([H])O3)([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C18H26N4O23P4.4Na/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30,,,,/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30),,,,/q,4*+1/p-4/t7-,8-,11-,12-,13-,14-,15-,16-,,,,/m1..../s1. InChi Key: OWTGMPPCCUSXIP-FNXFGIETSA-J.