Diphencyprone

Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.Formal Name: 2,3-diphenyl-2-cyclopropen-1-one. CAS Number: 886-38-4. Synonyms: Diphenylcyclopropenone, DPC, NSC 57541. Molecular Formula: C15H10O. Formula Weight: 206.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 14 mg/ml. lambdamax: 220, 227, 299 nm. SMILES: O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3. InChi Code: InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H. InChi Key: HCIBTBXNLVOFER-UHFFFAOYSA-N.