Dimethoxycurcumin

Dimethoxycurcumin is a derivative of curcumin (Cay-81025) that has anti-inflammatory and antioxidant activities. It inhibits mitogen-induced proliferation of CD4+ T cells, CD8+ T cells, and B cells, as well as secretion of IL-2, IL-4, IL-6, and IFN-gamma induced by concanavalin A (Cay-14951) in isolated human lymphocytes when used at concentrations ranging from 1 to 10 µM. Dimethoxycurcumin (1-10 µM) inhibits LPS-induced nitric oxide (NO) production and expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. It inhibits hemolysis of isolated human red blood cells (RBCs) induced by AAPH (Cay-82235) when used at a concentration of 10 µM.Formal Name: 1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione. CAS Number: 160096-59-3. Synonyms: Di-O-methylcurcumin. Molecular Formula: C23H24O6. Formula Weight: 396.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:2): 0.30 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 418 nm. SMILES: COC1=C(OC)C=C(/C=C/C(CC(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=O)C=C1. InChi Code: InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-14H,15H2,1-4H3/b9-5+,10-6+. InChi Key: HMJSBVCDPKODEX-NXZHAISVSA-N.