Dihydrofolic Acid

Dihydrofolic acid is an active metabolite of folic acid (Cay-20515) and an intermediate in the biosynthesis of both purines and pyrimidines. It is formed via the NADH-dependent reduction of folic acid by dihydrofolate reductase (DHFR). Dihydrofolic acid (10, 50, and 100 µg/ml) reduces insulin-like growth factor 1 receptor (IGF-1R) promotor activity in a cell-based reporter assay.Formal Name: N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid. CAS Number: 4033-27-6. Synonyms: NSC 165989. Molecular Formula: C19H21N7O6. Formula Weight: 443.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml. lambdamax: 222, 281 nm. SMILES: O=C1C2=C(NC(N)=N1)NCC(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=N2. InChi Code: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1. InChi Key: OZRNSSUDZOLUSN-LBPRGKRZSA-N.