Dexloxiglumide

Dexloxiglumide is a cholecystokinin (CCK) receptor antagonist and is the single (R) isomer of loxiglumide (Cay-25534). It selectively binds to the CCK1 receptor over CCK2 in CHO cells expressing the rat receptors (Kis = 0.0234 and 5.88 µM, respectively). Dexloxiglumide (20 µmol/kg) inhibits guinea pig gallbladder contractions induced by the CCK agonist CCK octapeptide (sulfated) (CCK-8S, Cay-23371). It reduces CCK-8-induced gastric emptying in rats (ID50 = 1.14 mg/kg).Formal Name: (4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-pentanoic acid. CAS Number: 119817-90-2. Molecular Formula: C21H30Cl2N2O5. Formula Weight: 461.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml, sonicated. SMILES: CCCCCN(CCCOC)C([C@@H](CCC(O)=O)NC(C1=CC(Cl)=C(C=C1)Cl)=O)=O. InChi Code: InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)/t18-/m1/s1. InChi Key: QNQZBKQEIFTHFZ-GOSISDBHSA-N.