Desacetyl Bisacodyl

Desacetyl bisacodyl (DAB) is an active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate. DAB evokes several effects at the colon or rectum, including increased mucus and chloride secretion. Oral administration of bisacodyl leads to decreased expression of aquaporin-3 in the colon of rats. The effects of both DAB and bisacodyl can be blocked with cyclooxygenase (COX) inhibitors, suggesting that products of the COX signaling pathway contribute to laxative effects.Formal Name: 4,4'-(2-pyridinylmethylene)bis-phenol. CAS Number: 603-41-8. Synonyms: DAB, DDPM. Molecular Formula: C18H15NO2. Formula Weight: 277.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 229, 267 nm. SMILES: OC(C=C1)=CC=C1C(C2=CC=CC=N2)C3=CC=C(O)C=C3. InChi Code: InChI=1S/C18H15NO2/c20-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(21)11-7-14/h1-12,18,20-21H. InChi Key: LJROKJGQSPMTKB-UHFFFAOYSA-N.