Derquantel

Derquantel is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist, causing flaccid paralysis and expulsion of nematodes. A combination of derquantel and the macrocyclic lactone, abamectin (Cay-19201), has been found to have synergistic anthelmintic effects against gastrointestinal nematode parasites in sheep.Formal Name: (1'R,5'aS,7'R,8'aS,9'aR)-2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one. CAS Number: 187865-22-1. Synonyms: PF-00520904, PNU 141962, 2-deoxy-Paraherquamide. Molecular Formula: C28H37N3O4. Formula Weight: 479.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CC(C=CO1)(C)OC2=C1C(NC3)=C(C=C2)[C@]3(C4(C)C)C[C@]5(N(C)C6=O)[C@@]4([H])C[C@]6([C@](C)(O)CC7)N7C5. InChi Code: InChI=1S/C28H37N3O4/c1-23(2)10-12-34-21-18(35-23)8-7-17-20(21)29-15-26(17)14-27-16-31-11-9-25(5,33)28(31,22(32)30(27)6)13-19(27)24(26,3)4/h7-8,10,12,19,29,33H,9,11,13-16H2,1-6H3/t19-,25+,26-,27+,28-/m0/s1. InChi Key: DYVLXWPZFQQUIU-WGNDVSEMSA-N.