Deoxypodophyllotoxin

Deoxypodophyllotoxin (DPT) is a flavolignan that has been found in J. sabina and has diverse biological activities. It inhibits tubulin polymerization in a cell-free assay when used at a concentration of 50 nM. DPT in also inhibits COX-2 and 5-lipoxygenase (5-LO) in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC50s = 1.89 and 0.37 µM, respectively). It reduces viral yield in the supernatant of MRC-5 cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 0.02 µg/ml. DPT inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in a concentration-dependent manner. It induces mortality in P. rapae fifth instar larvae (LC50 = 0.02 g/L). DPT (70 µg/kg) reduces tumor growth in a CT26 murine colon cancer model.Formal Name: (5R,5aR,8aR)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS Number: 19186-35-7. Synonyms: Anthricin, (-)-Deoxypodophyllotoxin, 4-Deoxypodophyllotoxin, DPT, RD4-6266. Molecular Formula: C22H22O7. Formula Weight: 398.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble upon heating, Methanol: slightly soluble upon heating. SMILES: O=C1[C@]2([H])[C@@](C3=CC(OC)=C(C(OC)=C3)OC)([H])C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1. InChi Code: InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1. InChi Key: ZGLXUQQMLLIKAN-SVIJTADQSA-N. Origin: Synthetic.