delta-Tocotrienol

delta-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities. It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Cay-82220), or L-buthionine-(S,R)-sulfoximine (BSO, Cay-14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM. delta-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes. It inhibits LPS-induced production of nitric oxide (NO), TNF-alpha, IL-6, IL-1beta, and IFN-gamma in RAW 264.7 cells. delta-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Cay-11439). [Matreya, LLC. Catalog No. 2112]Formal Name: 3,4-dihydro-2,8-dimethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol. CAS Number: 25612-59-3. Molecular Formula: C27H40O2. Formula Weight: 396.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 298 nm. SMILES: C/C(CC/C=C(C)/CC/C=C(C)/C)=C\CC[C@@]1(C)OC2=C(C)C=C(O)C=C2CC1. InChi Code: InChI=1S/C27H40O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1. InChi Key: ODADKLYLWWCHNB-LDYBVBFYSA-N.