Delphinidin chloride

Description: Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 µM, epithelial growth factor receptor signaling and estrogen receptor alpha expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 µM). Target: STAT, EGFR, Epigenetic Reader Domain, Apoptosis, VEGFR, JAK, Estrogen Receptor/ERR. Smiles: [Cl-].Oc1cc(O)c2cc(O)c([o+]c2c1)-c1cc(O)c(O)c(O)c1. References: Aiyer HS, et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. J Agric Food Chem. 2012,60(23):5693-5708.